Mixed Conditionals in Kannada grammar are a combination of different types of conditionals in the same sentence. They are used when the time in the 'if’ clause is not the same as the time in the 'main’ clause. They can express complex conditional situations that refer to both present outcomes of past conditions and present conditions causing future outcomes. Learning to use and understand these mixed conditional structures in Kannada can significantly enhance one’s proficiency and expressiveness in the language.